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Merck & Co molecular force field (mmff94) method
Molecular Force Field (Mmff94) Method, supplied by Merck & Co, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/molecular+force+field+(mmff94)+method/mmff94/pm39837406-95-14-14
Average 90 stars, based on 1 article reviews
molecular force field (mmff94) method - by Bioz Stars, 2026-09
90/100 stars

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Article Title: An Aldol-based Build/Couple/Pair Strategy for the Synthesis of Medium- and Large-sized Rings: Discovery of Macrocyclic Histone Deacetylase Inhibitors
Article Snippet: The energy-minimized structures were obtained by executing the stochastic search method using Merck Molecular Force Field (MMFF94) combined with the generalized Born (GB) solvation model of aqueous solvation as implemented in MOE.

Article Title: Coumarin benzamide scaffold as potential 5-HT 2C inhibitors: a multiparametric investigation and molecular simulation.
Article Snippet: Context This study investigates the interaction of synthetic coumarin benzamides (CmB1-10) obtained from the literature with the 5-HT2CR serotonergic receptor and the carbonic anhydrase II (CA-II) enzyme, with potential pharmacological applications in anxiety disorders.. CmB is a type of drug that has been shown to affect the 5-HT2CR receptor.. This receptor is involved in mood, thinking, and muscle control.

Article Title: Stealing from a distant neighbor: an unexpectedly fast long-span peroxy radical hydrogen-shift reaction in a long-chain diether
Article Snippet: First, conformational isomers of reactants, transition states and products are sampled with the Merck Molecular Force Field method (MMFF94) implemented in Spartan'24 (Wavefunction, Inc.).

Article Title: A Machine Learning Approach for Predicting Caco-2 Cell Permeability in Natural Products from the Biodiversity in Peru
Article Snippet: The 3D structures were then optimized using the steepest descent method with the Merck molecular force field 94 (MMFF 94) [ ].

Article Title: Evaluation of the Activity of Amino Chalcone Against Staphylococcus Strains Harboring Efflux Pumps
Article Snippet: Subsequently, AutoDock VinaTM ( https://vina.scripps.edu/ ) was set to perform 50 independent simulations of 20 poses each, for all ligands optimized using the Merck Molecular Force Field method (MMFF94) in Avogadro 2 ( https://two.avogadro.cc/ ).

Generated:

Article Title: Assessing the Impact of Measurement Precision on Metabolite Identification Probability in Multidimensional Mass Spectrometry-Based, Reference-Free Metabolomics
Article Snippet: .. Trained on over 5,000 experimental CCS values, the 3D conformers were generated using the Experimental-Torsion Knowledge Distance Geometry (ETKDG) method and the Merck Molecular Force Field (MMFF94). ..

Software:

Article Title: Robinin Isolated From Solanum Asperum Exhibits Pharmacological Actions in the Central Nervous System of Adult Zebrafish (Danio rerio).
Article Snippet: This study investigated the anxiolytic, anticonvulsant and memory preservation effects of the flavonoid robinin.. The compound, administered at doses of 4, 20 and 40 mg/kg, did not show toxicity after 96 h of monitoring.. In behavioural experiments with zebrafish, robinin did not cause significant changes in motor functions, but it impairs locomotor activity and demonstrates anxiolytic properties, evidenced by the increase in the time spent in the clean zone of the protector.

Article Title: Computational approach towards the design of artemisinin–thymoquinone hybrids against main protease of SARS-COV-2
Article Snippet: Adapted from PubChem The molecules were designed using the MarvinSketch ® academic license software version 20.13 [ ] from the ChemAxon © Marvin software package ( https://chemaxon.com/products/marvin ). .. The three-dimensional structure of the selected compounds was optimized using the classic force field method MMFF94 (Merck Molecular Force Field 94) [ ], implanted in the free Avogadro ® software [ ], programmed to perform a cycle of 4 interactions of the Steepest Descent algorithm, following the parameters defined in Eq. , where the most stable structure is obtained by minimizing the potential energy ( E ) of a molecule in its steady state, with the contribution of a force ( k b ) exerted on a bond between two atoms ( r − r 0 ) and the sum includes all bonds of the molecule's three-dimensional space [ ]. ..



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